Physiopathology of Parkinson's Disease 2020

›8:00 (30min)

Accueil des participants

8:00 - 8:30 (30min)

Accueil des participants

Inscriptions et café

›8:30 (30min)

Introduction

8:30 - 9:00 (30min)

Introduction

›9:00 (1h40)

Session 1 : Analyses génomiques - Génétique et Transcriptomique
Olga Corti, Marie-Christine Chartier-Harlin

9:00 - 10:40 (1h40)

Session 1 : Analyses génomiques - Génétique et Transcriptomique

Olga Corti, Marie-Christine Chartier-Harlin

› An update on the Genetics of Parkinson's disease - Vincenzo Bonifati, Erasmus University Medical Center, Rotterdam 09:00-09:30 (30min)

› GBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association study - Agustin Ruiz, Fundacio ACE [Barcelona] 09:30-10:00 (30min)

› Transcriptomic signatures of brain regional vulnerability to Parkinson's disease - Arlin Keo, Delft Bioinformatics Lab, Delft University of Technology [Delft], Leiden Computational Biology Center, Leiden University Medical Center 10:00-10:30 (30min)

› Mitochondrial dysfunctions caused by neuron-related RNA binding protein misexpression - Stylianos Ravanidis, Basic Sciences Division I, Biomedical Research Foundation, Academy of Athens, 11527 Athens 10:30-10:35 (05min)

› Deciphering the cellular and molecular response of human dopaminergic neurons to mitochondrial stress - Jana Heneine, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute 10:35-10:40 (05min)

›10:40 (20min)

Pause café

10:40 - 11:00 (20min)

Pause café

›11:00 (1h40)

Session 2 : Avancées récentes en Imagerie
Emmanuel Brouillet, Nadja Van Camp

11:00 - 12:40 (1h40)

Session 2 : Avancées récentes en Imagerie

Emmanuel Brouillet, Nadja Van Camp

› Can we use brain connectivity to improve individual patient DBS outcomes? - Brian Lau, Institut du Cerveau et de la Moelle épinière 11:00-11:30 (30min)

› Multimodal MRI in Parkinson's disease and parkinsonian syndromes - Patrice Péran - Toulouse NeuroImaging Centre (ToNIC) 11:30-12:00 (30min)

› Pathophysiology of dyskinesia and behavioral disorders in non-human primates: Insights from multimodal imaging - Véronique Sgambato - Institut des Sciences Cognitives Marc Jeannerod, Bron 12:00-12:30 (30min)

› Evaluation of dopaminergic neuronal loss and synaptic changes in an α-synuclein overexpressing model of PD - Pauline Roost, CNRS, UMR9199, CEA, DRF, IBFJ, MIRCen 12:30-12:35 (05min)

›12:40 (1h20)

Déjeuner et Posters

12:40 - 14:00 (1h20)

Déjeuner et Posters

›14:00 (1h40)

Session 3 : Qu'apprenons-nous des inclusions d'a-synucléine ?
Vincenzo Bonifati, Luc Bousset

14:00 - 15:40 (1h40)

Session 3 : Qu'apprenons-nous des inclusions d'a-synucléine ?

Vincenzo Bonifati, Luc Bousset

› Neuropathology of Parkinson' s disease and dementia of Lewy Bodies. - Charles Duyckaerts, Département de Neuropathologie Raymond Escourolle, Groupe Hospitalier Universitaire Pitié-Salpêtrière 14:00-14:30 (30min)

› Neuronal Parkinson inclusions are different than expected - Henning Stahlberg, Center for Cellular Imaging and Nanoanalytics (C-CINA) 14:30-15:00 (30min)

› 3D structure determination of amyloid fibrils using solid-state NMR spectroscopy. - 15:00-15:30 (30min)

› Alpha-synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb - Nolwen Rey, MIRCen, CEA & CNRS UMR 9199, Fontenay-aux-Roses 15:30-15:35 (05min)

› GCI-induced neurodegeneration and synucleinopathy in non-human primates - Margaux Teil, Institut des Maladies Neurodégénératives [Bordeaux] 15:35-15:40 (05min)

›15:40 (20min)

Pause café

15:40 - 16:00 (20min)

Pause café

›16:00 (1h40)

Session 4 : Localisation et régulation de l'a-synucléine
Sabine Hilfiker, Stéphane Hunot

16:00 - 17:40 (1h40)

Session 4 : Localisation et régulation de l'a-synucléine

Sabine Hilfiker, Stéphane Hunot

› Alpha-synuclein: a troublesome traveller - Donato Di Monte, German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen 16:00-16:30 (30min)

› Posttranslational modifications: modulators of alpha-synuclein biology and pathobiology - Tiago Fleming Outeiro - University Medical Center Goettingen 16:30-17:00 (30min)

› Transcriptional regulation of alpha-synuclein by the TRIM17-TRIM41-ZSCAN21 pathway - Solange Desagher, Institute of Molecular Genetics of Montpellier, UMR 5535 CNRS-Université de Montpellier 17:00-17:30 (30min)

› Characterising the role of alpha synuclein in Ferroptosis in the context go Parkinson's disease - Laura Mahoney Sanchez, University and University Hospital of Lille, INSERM UMRS_1171, LICEND COEN Center 17:30-17:35 (05min)

› Identification of targets and markers of Parkinson's disease-associated neuroinflammation - Cansu YILDIRIM, Brain and Spine Institute (ICM) 17:35-17:40 (05min)

›17:40 (20min)

Pause

17:40 - 18:00 (20min)

Pause

›18:00 (2h)

Session 5 : Patients & associations
Emmanuel Brouillet, Marie-Christine Chartier-Harlin

18:00 - 20:00 (2h)

Session 5 : Patients & associations

Emmanuel Brouillet, Marie-Christine Chartier-Harlin

› Association France Parkinson - Marie Fuzzati, Guy Janet Maitre - Association France Parkinson 18:00-18:20 (20min)

› Fondation Vaincre Alzheimer - Maï Panchal, Directrice Scientifique de la Fondation Vaincre Alzheimer 18:20-18:30 (10min)

› Brain biobanking - Charles Duyckaerts, Département de Neuropathologie Raymond Escourolle, Groupe Hospitalier Universitaire Pitié-Salpêtrière 18:30-18:40 (10min)

› Conférence plénière ouverte au public : La chirurgie dans la maladie de Parkinson, état de l'art et perspectives - Stéphane PALFI, CHU Henri Mondor, Créteil 18:45-19:45 (1h)