Schedule
Wednesday, January 29, 2020
Thursday, January 30, 2020
| Time |
Event |
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08:00 - 08:30
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Participants welcome - Registration and coffee |
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08:30 - 09:00
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Introduction |
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09:00 - 10:40
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Topic 1: Genome wide Analyses - Genetics and Transcriptomics - Olga Corti, Marie-Christine Chartier-Harlin |
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09:00 - 09:30 |
› An update on the Genetics of Parkinson's disease - Vincenzo Bonifati, Erasmus University Medical Center, Rotterdam |
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09:30 - 10:00 |
› GBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association study - Agustin Ruiz, Fundacio ACE [Barcelona] |
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10:00 - 10:30 |
› Transcriptomic signatures of brain regional vulnerability to Parkinson's disease - Arlin Keo, Delft Bioinformatics Lab, Delft University of Technology [Delft], Leiden Computational Biology Center, Leiden University Medical Center |
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10:30 - 10:35 |
› Mitochondrial dysfunctions caused by neuron-related RNA binding protein misexpression - Stylianos Ravanidis, Basic Sciences Division I, Biomedical Research Foundation, Academy of Athens, 11527 Athens |
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10:35 - 10:40 |
› Deciphering the cellular and molecular response of human dopaminergic neurons to mitochondrial stress - Jana Heneine, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute |
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10:40 - 11:00
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Coffee break |
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11:00 - 12:40
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Topic 2: Recent advances in Imaging - Emmanuel Brouillet, Nadja Van Camp |
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11:00 - 11:30 |
› Can we use brain connectivity to improve individual patient DBS outcomes? - Brian Lau, Institut du Cerveau et de la Moelle épinière |
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11:30 - 12:00 |
› Multimodal MRI in Parkinson's disease and parkinsonian syndromes - Patrice Péran - Toulouse NeuroImaging Centre (ToNIC) |
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12:00 - 12:30 |
› Pathophysiology of dyskinesia and behavioral disorders in non-human primates: Insights from multimodal imaging - Véronique Sgambato - Institut des Sciences Cognitives Marc Jeannerod, Bron |
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12:30 - 12:35 |
› Evaluation of dopaminergic neuronal loss and synaptic changes in an α-synuclein overexpressing model of PD - Pauline Roost, CNRS, UMR9199, CEA, DRF, IBFJ, MIRCen |
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12:40 - 14:00
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Lunch and Posters |
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14:00 - 15:40
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Topic 3: What do we learn from a-synuclein inclusions? - Vincenzo Bonifati, Luc Bousset |
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14:00 - 14:30 |
› Neuropathology of Parkinson' s disease and dementia of Lewy Bodies. - Charles Duyckaerts, Département de Neuropathologie Raymond Escourolle, Groupe Hospitalier Universitaire Pitié-Salpêtrière |
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14:30 - 15:00 |
› Neuronal Parkinson inclusions are different than expected - Henning Stahlberg, Center for Cellular Imaging and Nanoanalytics (C-CINA) |
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15:00 - 15:30 |
› 3D structure determination of amyloid fibrils using solid-state NMR spectroscopy. - Antoine Loquet - Chimie et Biologie des Membranes et des Nanoobjets |
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15:30 - 15:35 |
› Alpha-synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb - Nolwen Rey, MIRCen, CEA & CNRS UMR 9199, Fontenay-aux-Roses |
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15:35 - 15:40 |
› GCI-induced neurodegeneration and synucleinopathy in non-human primates - Margaux Teil, Institut des Maladies Neurodégénératives [Bordeaux] |
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15:40 - 16:00
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Coffee break |
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16:00 - 17:40
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Topic 4: Localisation and regulation of a-synuclein - Sabine Hilfiker, Stéphane Hunot |
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16:00 - 16:30 |
› Alpha-synuclein: a troublesome traveller - Donato Di Monte, German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen |
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16:30 - 17:00 |
› Posttranslational modifications: modulators of alpha-synuclein biology and pathobiology - Tiago Fleming Outeiro - University Medical Center Goettingen |
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17:00 - 17:30 |
› Transcriptional regulation of alpha-synuclein by the TRIM17-TRIM41-ZSCAN21 pathway - Solange Desagher, Institute of Molecular Genetics of Montpellier, UMR 5535 CNRS-Université de Montpellier |
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17:30 - 17:35 |
› Characterising the role of alpha synuclein in Ferroptosis in the context go Parkinson's disease - Laura Mahoney Sanchez, University and University Hospital of Lille, INSERM UMRS_1171, LICEND COEN Center |
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17:35 - 17:40 |
› Identification of targets and markers of Parkinson's disease-associated neuroinflammation - Cansu YILDIRIM, Brain and Spine Institute (ICM) |
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17:40 - 18:00
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Break |
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18:00 - 20:00
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Topic 5: Patients & associations - Emmanuel Brouillet, Marie-Christine Chartier-Harlin |
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18:00 - 18:20 |
› Association France Parkinson - Marie Fuzzati, Guy Janet Maitre - Association France Parkinson |
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18:20 - 18:30 |
› Fondation Vaincre Alzheimer - Maï Panchal, Directrice Scientifique de la Fondation Vaincre Alzheimer |
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18:30 - 18:40 |
› Brain biobanking - Charles Duyckaerts, Département de Neuropathologie Raymond Escourolle, Groupe Hospitalier Universitaire Pitié-Salpêtrière |
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18:45 - 19:45 |
› Conférence plénière ouverte au public : La chirurgie dans la maladie de Parkinson, état de l'art et perspectives - Stéphane PALFI, CHU Henri Mondor, Créteil |
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| Time |
Event |
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08:30 - 09:00
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Welcome - Coffee |
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09:00 - 10:40
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Topic 6: Molecular modelling using other Parkinson's disease genes - Tiago Outeiro, Cristine Alves Da Costa |
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09:00 - 09:30 |
› The role of Lipid Droplets in Parkinson's Disease - Bertrand Mollereau, Laboratoire de Biologie Moléculaire de la Cellule, Lyon |
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09:30 - 10:00 |
› Mitochondrial functions of PINK1 - Vanessa Morais, Instituto de Medicina Molecular (iMM) Lisboa |
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10:00 - 10:30 |
› Cellular mechanisms underlying LRRK2-related Parkinson´s disease - Sabine Hilfiker, Rutgers University, New Jersey Medical School |
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10:30 - 10:35 |
› Triallelic stem cell model of Parkinson's disease reveals epistatic interaction between PRKN and GBA - Zoé Hanss, Luxembourg Centre For Systems Biomedicine |
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10:35 - 10:40 |
› LRRK2 interacts with a subset of endosomal vesicular SNAREs: potential role in the physiopathology of Parkinson Disease - Francesca Filippini, Institut de Psychiatrie et Neuroscience de Paris |
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10:40 - 11:00
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Coffee break |
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11:00 - 12:40
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Topic 7: Preclinical and Translational developments - Emmanuel Brouillet, Erwan Bézard |
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11:00 - 11:30 |
› Impulse control disorders and levodopa-induced dyskinesias in Parkinson's disease - Pierre-Olivier Fernagut, Laboratoire de Neurosciences Expérimentales et Cliniques, Poitiers |
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11:30 - 12:00 |
› From bench to bedside in a peculiar synucleopathy: the multiple system atrophy - Wassilios Meissner, Institut des Maladies Neurodégénératives, Bordeaux |
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12:00 - 12:30 |
› A brain-spine interface alleviating gait deficits in a primate model of parkinson's disease - Jocelyne Bloch-Pasche, Centre Hospitalier Universitaire Vaudois, Lausanne |
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12:30 - 12:35 |
› Acidic nanoparticles prevent neurodegeneration in LB-induced Parkinson's disease mouse model - Marie-Laure AROTCARENA, Institut des Maladies Neurodégénératives [Bordeaux] |
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12:35 - 12:40 |
› Potential of dopamine neurons derived from human induced pluripotent stem cells reprogrammed by mRNA for Parkinson's disease - Sébastien BROT, Laboratoire de neurosciences expérimentales et cliniques |
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12:40 - 14:00
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Lunch - Posters |
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14:00 - 14:30
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Sponsored presentation: Axion BioSytems - Giovanna De Filippi |
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14:30 - 15:40
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Topic 8: From single cell to 3D models (1) - Richard Wade-Martins, Anselme Perrier |
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14:30 - 15:00 |
› Cellular Brain Repair for Parkinson's Disease: Is the Answer in the (Biomaterial) Matrix? - Eilis Dowd, Pharmacology & Therapeutics, National University of Ireland, Galway, Ireland |
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15:00 - 15:30 |
› iPSC neuronal models of Parkinson's: from pathological mechanisms to target discovery - Richard Wade-Martins - Oxford Parkinson's Disease Centre - Department of Physiology, Anatomy and Genetics, University of Oxford |
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15:30 - 15:35 |
› Specific vulnerability of neuronal populations & Transfer of alpha-synuclein in reconstructed neural networks - Josquin Courte, Physico-Chimie-Curie, Neuroscience Paris Seine |
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15:40 - 16:00
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Coffee break |
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16:00 - 17:00
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Topic 8: from single cell to 3D models (2) - Eilis Dowd, Anselme Perrier |
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16:00 - 16:30 |
› New insights into the complex role of mitochondria in Parkinson's disease - Anne Grünewald, Luxembourg Centre for Systems Biomedicine |
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16:30 - 17:00 |
› 3D Cultures of Parkinson's Disease‐Specific Dopaminergic Neurons for High Content Phenotyping and Drug Testing - Jens Christian Schwamborn, Luxembourg Centre for Systems Biomedicine |
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17:00 - 18:00
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Awards and conclusion |
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